April 21 in Minnesota Twins History: The Twins play their first home game, losing to the ‘new’ expansion Washington Senators at Metropolitan Stadium (1961)

On April 21, 1961 — The Twins, formerly known as the Washington Senators before moving to Minnesota, play their first home game, losing to the ‘new’ expansion Washington Senators, 5-3 in front of a crowd of 24,606 at Metropolitan Stadium. The club’s move to the North Star State will attract 1,256,72

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Source: Historical record

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