On May 18, 1961 — Los Angeles Angels pitcher Ryne Duren posts four strikeouts in the 7th inning against the Chicago White Sox . He strikes out Minnie Miñoso, Roy Sievers, J.C. Martin, and Sammy Esposito to tie a major league record, in the 6 – 4 loss to the White Sox. Source: Baseball Reference May
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Source: Historical record